In questions 4-7, refer to the scheme below. Maxigesic is a combination analgesic containing acetaminophen (500 mg) and ibuprofen (150 mg) with a starch binder. Finish the flowchart to show how you could separate acetaminophen and ibuprofen using acid-base extractions. (Note: the pKa of ibuprofen is about 4.9 and the pKa of acetaminophen is 9.5). 4. Refer to letter A: Indicate the pH of a buffered aqueous solution that would selectively remove ibuprofen from the organic layer. 5. Refer to the funnel marked B: What compound is in the upper layer, and is it in an ionized or unionized form? 6. Refer to letter C: Indicate what solution is needed to cause the dissolved compound to precipitate, and identify the precipitate that forms. 7. Refer to letter D: Indicate what technique could be used to isolate the organic solid, and identify the solid that forms. ether

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Chapter1: Chemical Foundations
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In questions 4-7, refer to the scheme below. Maxigesic is a combination analgesic containing
acetaminophen (500 mg) and ibuprofen (150 mg) with a starch binder. Finish the flowchart to show
how you could separate acetaminophen and ibuprofen using acid-base extractions. (Note: the pKa of
ibuprofen is about 4.9 and the pKa of acetaminophen is 9.5).
4. Refer to letter A: Indicate the pH of a buffered aqueous solution that would selectively
remove ibuprofen from the organic layer.
5. Refer to the funnel marked B: What compound is in the upper layer, and is it in an ionized or
unionized form?
6. Refer to letter C: Indicate what solution is needed to cause the dissolved compound to
precipitate, and identify the precipitate that forms.
7. Refer to letter D: Indicate what technique could be used to isolate the organic solid, and
identify the solid that forms.
ether
Maxigesic
tablet
D
technique:
В
top layer
A
sBu
pH range:
OH
-NH
bottom layer
C
solution to add:
Transcribed Image Text:In questions 4-7, refer to the scheme below. Maxigesic is a combination analgesic containing acetaminophen (500 mg) and ibuprofen (150 mg) with a starch binder. Finish the flowchart to show how you could separate acetaminophen and ibuprofen using acid-base extractions. (Note: the pKa of ibuprofen is about 4.9 and the pKa of acetaminophen is 9.5). 4. Refer to letter A: Indicate the pH of a buffered aqueous solution that would selectively remove ibuprofen from the organic layer. 5. Refer to the funnel marked B: What compound is in the upper layer, and is it in an ionized or unionized form? 6. Refer to letter C: Indicate what solution is needed to cause the dissolved compound to precipitate, and identify the precipitate that forms. 7. Refer to letter D: Indicate what technique could be used to isolate the organic solid, and identify the solid that forms. ether Maxigesic tablet D technique: В top layer A sBu pH range: OH -NH bottom layer C solution to add:
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