In order to complete the synthesis shown below, you would need to use [ Select ] as the nucleophile source and [ Select ] as the solvent. H3C OH H3C Br H3 H3C- CH3 CH3

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**Title: Understanding Nucleophilic Substitution Reactions**

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**Synthesis Problem:**

In order to complete the synthesis shown below, you would need to use **[Select]** as the nucleophile source and **[Select]** as the solvent.

**Chemical Reaction Diagram:**

- On the left side of the reaction, we have the starting material:
  - Chemical Structure: 
    - The molecule contains a central carbon atom bonded to three other groups: 
      - To the left, a methyl group (CH₃).
      - Below, another methyl group (CH₃).
      - Above, a hydroxyl group (OH).
      - To the right, a hydrogen atom (H).

- An arrow points towards the right side, indicating a chemical reaction proceeding from left to right.

- On the right side of the reaction, we have the product:
  - Chemical Structure: 
    - The molecule has the same central carbon atom bonded to:
      - To the left, a methyl group (CH₃).
      - Below, another methyl group (CH₃).
      - Above, a bromine atom (Br).
      - To the right, a hydrogen atom (H).

**Description:**

This reaction demonstrates a typical nucleophilic substitution reaction where the nucleophile (which needs to be selected) will replace the hydroxyl group (-OH) in the starting material with a bromine atom (Br) to form the final product.

**Key Points to Consider:**

1. **Nucleophile Selection:** 
   - A good nucleophile source is required to initiate the substitution reaction. The nucleophile must be strong enough to displace the hydroxyl group.
   
2. **Solvent Selection:**
   - The choice of solvent can significantly affect the reaction mechanism and the overall reaction efficiency. It is important to choose a solvent that will best facilitate the nucleophilic substitution.

---

**Additional Notes:**

Understanding the characteristics of the nucleophile and the solvent is crucial in successfully carrying out substitution reactions. This particular reaction is an example of the transformation of an alcohol into an alkyl halide, which is a common operation in organic synthesis used to introduce halogen functionality into organic molecules. 

Use the dropdown menus to explore and select the appropriate reagents and solvents that would drive this reaction forward successfully.
Transcribed Image Text:**Title: Understanding Nucleophilic Substitution Reactions** --- **Synthesis Problem:** In order to complete the synthesis shown below, you would need to use **[Select]** as the nucleophile source and **[Select]** as the solvent. **Chemical Reaction Diagram:** - On the left side of the reaction, we have the starting material: - Chemical Structure: - The molecule contains a central carbon atom bonded to three other groups: - To the left, a methyl group (CH₃). - Below, another methyl group (CH₃). - Above, a hydroxyl group (OH). - To the right, a hydrogen atom (H). - An arrow points towards the right side, indicating a chemical reaction proceeding from left to right. - On the right side of the reaction, we have the product: - Chemical Structure: - The molecule has the same central carbon atom bonded to: - To the left, a methyl group (CH₃). - Below, another methyl group (CH₃). - Above, a bromine atom (Br). - To the right, a hydrogen atom (H). **Description:** This reaction demonstrates a typical nucleophilic substitution reaction where the nucleophile (which needs to be selected) will replace the hydroxyl group (-OH) in the starting material with a bromine atom (Br) to form the final product. **Key Points to Consider:** 1. **Nucleophile Selection:** - A good nucleophile source is required to initiate the substitution reaction. The nucleophile must be strong enough to displace the hydroxyl group. 2. **Solvent Selection:** - The choice of solvent can significantly affect the reaction mechanism and the overall reaction efficiency. It is important to choose a solvent that will best facilitate the nucleophilic substitution. --- **Additional Notes:** Understanding the characteristics of the nucleophile and the solvent is crucial in successfully carrying out substitution reactions. This particular reaction is an example of the transformation of an alcohol into an alkyl halide, which is a common operation in organic synthesis used to introduce halogen functionality into organic molecules. Use the dropdown menus to explore and select the appropriate reagents and solvents that would drive this reaction forward successfully.
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