In general, which of the following statements about nucleophilic reactions are true ? Select all that apply. | Steric hindrance in the substrate is irrelevant in SN1 reactions. E2 reactions rely on least substituted substrates. 1° are best while 3° are worst. Hindered strong bases are expected to result in Hoffman products whenever feasible.
In general, which of the following statements about nucleophilic reactions are true ? Select all that apply. | Steric hindrance in the substrate is irrelevant in SN1 reactions. E2 reactions rely on least substituted substrates. 1° are best while 3° are worst. Hindered strong bases are expected to result in Hoffman products whenever feasible.
Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:In general, which of the following statements about nucleophilic reactions are true? Select all that apply.
- ☐ Steric hindrance in the substrate is irrelevant in \( S_N1 \) reactions.
- ☑ E2 reactions rely on least substituted substrates. 1° are best while 3° are worst.
- ☑ Hindered strong bases are expected to result in Hoffman products whenever feasible.
- ☐ Polar aprotic solvents like HMPA, DMF, DMSO, acetonitrile, or acetone are preventing \( S_N1/E1 \) reactions.
- ☑ Polar protic, neutral or acidic solvents/environments like alcohols, water, or acidic solutions inhibit \( S_N2 \) mechanism.

Transcribed Image Text:1. Hindered strong bases are expected to result in Hoffman products whenever feasible. ☑️
2. Polar aprotic solvents like HMPA, DMF, DMSO, acetonitrile, or acetone are preventing S<sub>N</sub>1/E1 reactions.
3. Polar protic, neutral or acidic solvents/environments like alcohols, water, or acidic solutions inhibit S<sub>N</sub>2 mechanism. ☑️
4. E2 reactions rely on antiperiplanar conformation with respect to the leaving group and the hydrogen that are being eliminated. ☑️
5. E1 reactions do not depend on the performance of the leaving group.
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