In-class question 8: Calculate the net charge of the following peptide at pH 7 and pH 14. NEVERCRY ■ A: +1, -3 Sidechain of Charge in the Charge in pKa wwww ▪ B: 0, -4 Amino acid acid form the basic form ▪ C: 0, -5 Arg (R) +1 0. 12.5 wwww ▪ D: -1, -6 Lys (K) +1 0 10.0 His (H) +1 0 6.0 Asp (D) 0 -1 3.9 Glu (E) Cys (C) Tyr (Y) Amino End Carboxylic End oooo 0 -1 4.2 0 -1 8.3 0 -1 10.1 +1 0 9.0 -1 2.0

Which of the natural amino acids below are basic? HO H₂N 00000 NH₂ Glycine (Gly; G) OH NH₂ Serine (Ser; S) NH NH₂ Methionine (Met; M) Gly Ala Val Leu Phe OH Me. Arginine (Arg; R) HS OH HO NH₂ NH₂ Alanine (Ala; A) OH NH₂ Cysteine (Cys; C) OH OH THE NH₂ NH₂ Threonine (Thr; T) OH H₂N. Valine (Val, V) HN OH EN H₂N NH₂ Histidine (His; H) NH₂ Asparagine (Asn; N) H Glutamine (Gln; Q) OH NH₂ Leucine (Leu; L) NH₂ OH OH НО, OH HO O NH₂ Aspartic acid (Asp; D) NH₂ Glutamic acid (Glu; E) Phenylalanine (Phe; F) HN NH₂ Tryptophan (Trp; W) NH₂ OH H₂N OH OH OH H₂N. HO ΝΗ Lysine (Lys; K) Proline (Pro; P) NH₂ OH OH O NH₂ Asparagine (Asn ; N) Tyrosine (Tyr; Y) OH NH₂ OH

Erythromycin is a weak base with a pka of= 5.2 What will be the ionisation state of the drug in stomach, small intestine and blood? what is the site of absorption of this drug? pH stomach = 1.5, pH blood = 7.4, pH of small intestine is 6.5.

Give detailed Solution with explanation (no need Handwritten

2. Classify the following amino acids as nonpolar, polar basic, polar acidic, or polar neutral. (a) (b) (c) (d) H₂N-CH-COH CH-OH I CH3 || H₂N-CH-C-OH I CH₂ C=O 1 OH H₂N-CH-C-OH CH₂ T CH-CH3 CH₂ H₂N-CH-C-OH ī CH₂ OH 229

Plz explain to me. At the second midpoint of a diprotic amino acid, it will be a) In equal proportions with its conjugate base after the first ionization. b) In unequal proportions with its conjugate base. c) Completely protonated. d) Completely deprotonated.

dont provide handwriting solution ...

Which of the following is true concerning the amino acid shown here? || H3N-CH-C-o A) The pH is below the pl. CH2 B) The pH is above the pl. C) The pH has the same value as the pl. D) It is not possible to determine the pH.

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Lysine and tryptophan are two amino acids that contain an additional Natom in the R group bonded to the a carbon. While lysine is classified asa basic amino acid because it contains an additional basic N atom,tryptophan is classified as a neutral amino acid. Explain why thisdifference in classification occurs.