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- Assume presynaptic excitatory neuron A terminates on a postsynaptic cell near the axon hillock and presynaptic excitatory neuron B terminates on the same postsynaptic cell on a dendrite located on the side of the cell body opposite the axon hillock. Explain why rapid firing of presynaptic neuron A could bring the postsynaptic neuron to threshold through temporal summation, thus initiating an action potential, whereas firing of presynaptic neuron B at the same frequency and the same magnitude of EPSPs may not bring the postsynaptic neuron to threshold.Conformational changes in channel proteins brought about by voltage changes are responsible for opening and closing Na+ and K+ gates during the generation of an action potential. (True or false?)When action potentials arrive at a synapse between a neuron and another cell, they stimulate the release of molecules of a ________ that diffuse over to that cell.
- Describe the contribution of each of the following to the establishment and maintenance of membrane potential: Part A Na+K+ Pump Passive movement of K+ across the membrane Passive movement of Na+ across the membraneAssume the membrane is only permeable to Na+ and K+, the electrical model of axon membrane is the following: Outside A INa gna ENa Ex D Inside The membrane potential at rest and at peak is -70mV and 45mV respectively; the potential of Sodium ion is 60mV and the potential of Potassium ion is -80mV. Find the ratio 9Na at rest and at peak. gKDescribe the contribution of each of the following to the establishment and maintenance of membrane potential: Part A Na+K+ Pump Passive movement of K+ across the membrane Passive movement of Na+ across the membrane Part B Resting membrane potential is approximately -70mV. Explain what resting membrane potential is and what -70mV refers to.
- If a neuron is stimulated simultaneously by 2 stimuli at its dendrites (one generates a very large hyperpolarizing potential and the other generates a very small depolarizing potential). What would happen to this neuron? Group of answer choices The summation of these two graded potentials will generate an action potential and this action potential will travel down the axon. Summation of these two graded potentials will cause the membrane potential at the axon hillock to be more negative. These graded potentials will bring the resting membrane potential to 0 mV. These graded potentials with opposite polarity would therefore generate two action potentials and they will travel along this neuron in opposite direction.In the figure to the left, name the 4 phases of the action potential (Note: you have to write in where phase 4 occurs). Describe what happens in each phase with a focus on Na+ and K+ flow through channels and the membrane potential. Discuss the importance of threshold. How does this relate to the concept of APs being all or none?You generate action potentials in a neuron bathed in solution in a petri dish by applying a threshold-level depolarizing stimulus near its axon hillock. If the solution surrounding the neuron contained 5mM K+, 150 mM Na+, and 0 mM Ca2+ which of the following would you expect? The neuron would not be able to propagate action potentials down the entire length of the axon The neuron would not release neurotransmitter from the axon terminal The neurons action potentials would have an unusually long duration The neuron would have a resting membrane potential of zero
- At resting membrane potential for a typical neuron (-70 mV), which ion does NOT move?Na+Ca2+K+Cl-NoneA graded potential that achieves threshold leads to the generation of an action potential. Which one of the following statement/s regarding graded and action potentials is/are true? O graded potentials result from the opening of chemically gated sodium channels O action potentials result from the opening of voltage gated sodium channels O graded potentials result from the opening of calcium gated channels and action potentials result from the opening of sodium gated channels a and b NextResting potential is a balance across the axon membrane between______forces moving ions out of the cell and ______forces operating to keep ions in the cell.
