Imidazoleglycerol-phosphate dehydratase is an enzyme in the histine biosynthesis pathway. It catalyzes the El dehydration of D-erthyro-imidazole-glycerol phosphate to imidazole acetol-phosphate. This is a rare example of a biological El reaction, as most biological elimination reactions occur through ElcB instead. In this reaction, D-erthyro-imidazole-glycerol phosphate is first protonated to form a good leaving group. Then, the leaving group is ejected to form the resonance-stabilized carbocation shown. Draw curved arrows forming the most stable resonance structure to explain why this reaction goes through an E1 mechanism. Draw curved arrows to form the most stable resonance structure. Select Draw Rings More Erase : NH но: H
Catalysis and Enzymatic Reactions
Catalysis is the kind of chemical reaction in which the rate (speed) of a reaction is enhanced by the catalyst which is not consumed during the process of reaction and afterward it is removed when the catalyst is not used to make up the impurity in the product. The enzymatic reaction is the reaction that is catalyzed via enzymes.
Lock And Key Model
The lock-and-key model is used to describe the catalytic enzyme activity, based on the interaction between enzyme and substrate. This model considers the lock as an enzyme and the key as a substrate to explain this model. The concept of how a unique distinct key only can have the access to open a particular lock resembles how the specific substrate can only fit into the particular active site of the enzyme. This is significant in understanding the intermolecular interaction between proteins and plays a vital role in drug interaction.
Draw two curved arrows to give a stable resonance structure that fulfills the octet rule.
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