Identify the various drugs used to manage type 1 and type 2 diabetes mellitus

Body Structures & Functions
12th Edition
ISBN:9781285695495
Author:Scott
Publisher:Scott
Chapter11: Endocrine Systems
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Identify the various drugs used to manage type 1 and type 2 diabetes mellitus

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Step 1

Diabetes treatment for all people entails lifestyle adjustments such as diet and exercise.

To avoid diabetes complications, blood glucose levels must be monitored on a regular basis.
Insulin, as well as diet and exercise, are used to treat patients with type 1 diabetes.
Diet and exercise are frequently used to treat patients with type 2 diabetes.

Patients may be prescribed oral antihyperglycemic medications, injectable glucagon-like peptide-1 (GLP-1) receptor agonists, insulin, or a combination of these treatments if those methods are insufficient for glycemic control.
Drugs are frequently prescribed to diabetic patients to help them avoid problems.

Step 2

Insulin therapy is required for type 1 diabetes throughout one's life.

1. Rapid-acting Insulin:
Because the reversal of an amino acid pair inhibits the insulin molecule from combining into dimers and polymers, rapid-acting insulins, such as lispro and aspart, are rapidly absorbed.

They frequently start lowering plasma glucose within 15 minutes, but its effect is short-lived (less than 4 hours).

To control postprandial rises in plasma glucose, these insulins are best given at dinner. Regular insulin inhaled with meals is newer, faster-acting insulin.

2. Regular insulin: is marginally slower in onset (30 to 60 minutes) than lispro and  aspart but keeps going longer (6 to 8 hours). It is the as it were insulin form for IV use.

 3. Neutral protamine Hagedorn (NPH, or insulin isophane): is intermediate-acting; onset of activity is around 2 hours after infusionpeak impact is 4 to 12 hours after infusion, and term of activity is 18 to 26 hours. Concentrated normal insulin U-500 incorporates a comparable peak and length of activity (top 4 to 8 hours; term 13 to 24 hours) and can be dosed 2 to 3 times per day.
 
4. Unlike NPH, long-acting insulins, such as insulin glargine, insulin detemir, and U-300 insulin glargine, have no visible peak of activity and offer a consistent basal impact over a 24-hour period. Insulin degludec (another long-acting insulin) has a 40-hour action time. It is dosed daily, and while it takes three days to reach steady state, the dosing schedule is less restrictive.
5. Commercially available premixed formulations combine NPH and conventional insulin, as well as insulin lispro and NPL (neutral protamine lispro or a version of lispro adapted to act like NPH). NPA (neutral protamine aspart or a kind of aspart adapted to act like NPH) with insulin aspart and a premixed degludec and aspart formulation are two more premixed formulations.
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