Ibuprofen is a weak acid with a pK, of 4.9 (structure is shown with the ionizable hydrogen marked with a star). Ibuprofen is absorbed through the stomach and the small intestine. In these tissues, absorption is a function of polarity. Charged and very polar molecules are absorbed slowly; neutral hydrophobic molecules absorb quickly. If the stomach pH is about 1.5 and the small intestine pH is about 6, whem (and why) will more ibuprofen be absorbed into the bloodstream? OH* HgC HC CH ECH H3C „CH2 CH ČH3 More ibuprofen will be absorbed in the small intestine because it will be uncharged due to the pH being greater than the pK. O More ibuprofen will be absorbed in the stomach because it will be charged due to the pH being lower than the pK. O More ibuprofen will be absorbed in the small intestine because it will be charged due to the pH being greater than the pK. More ibuprofen will be absorbed in the stomach because it will be uncharged due to the pH being lower than the pk. Ibuprofen will be absorbed equally well in both the stomach and small intestine.

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
icon
Related questions
Question
Ibuprofen is a weak acid with a pK, of 4.9 (structure is shown with the ionizable hydrogen marked with a star). Ibuprofen is absorbed
through the stomach and the small intestine. In these tissues, absorption is a function of polarity. Charged and very polar molecules are
absorbed slowly; neutral hydrophobic molecules absorb quickly. If the stomach pH is about 1.5 and the small intestine pH is about 6, where
(and why) will more ibuprofen be absorbed into the bloodstream?
OH
HC
H3C CH2
CH3
O More ibuprofen will be absorbed in the small intestine because it will be uncharged due to the pH being greater than the pK.
O More ibuprofen will be absorbed in the stomach because it will be charged due to the pH being lower than the pK.
O More ibuprofen will be absorbed in the small intestine because it will be charged due to the pH being greater than the pk
O More ibuprofen will be absorbed in the stomach because it will be uncharged due to the pH being lower than the pK.
O Ibuprofen will be absorbed equally well in both the stomach and small intestine.
MacBook Air
80
888
esc
DII
DD
F1
F2
F3
F4
F5
F7
FB
F9
@
#3
$
&
1
3
4
6
8.
Q
W
T
Y
A
S
D
F
K
Z
C
この
* LO
Transcribed Image Text:Ibuprofen is a weak acid with a pK, of 4.9 (structure is shown with the ionizable hydrogen marked with a star). Ibuprofen is absorbed through the stomach and the small intestine. In these tissues, absorption is a function of polarity. Charged and very polar molecules are absorbed slowly; neutral hydrophobic molecules absorb quickly. If the stomach pH is about 1.5 and the small intestine pH is about 6, where (and why) will more ibuprofen be absorbed into the bloodstream? OH HC H3C CH2 CH3 O More ibuprofen will be absorbed in the small intestine because it will be uncharged due to the pH being greater than the pK. O More ibuprofen will be absorbed in the stomach because it will be charged due to the pH being lower than the pK. O More ibuprofen will be absorbed in the small intestine because it will be charged due to the pH being greater than the pk O More ibuprofen will be absorbed in the stomach because it will be uncharged due to the pH being lower than the pK. O Ibuprofen will be absorbed equally well in both the stomach and small intestine. MacBook Air 80 888 esc DII DD F1 F2 F3 F4 F5 F7 FB F9 @ #3 $ & 1 3 4 6 8. Q W T Y A S D F K Z C この * LO
Expert Solution
Step 1

The correct option is:

 

trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps with 1 images

Blurred answer
Knowledge Booster
The World Ocean
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Chemistry
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9780078021558
Author:
Janice Gorzynski Smith Dr.
Publisher:
McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Elementary Principles of Chemical Processes, Bind…
Elementary Principles of Chemical Processes, Bind…
Chemistry
ISBN:
9781118431221
Author:
Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:
WILEY