Iany diseases alter the ionic composition of the plasma, such as metabolic acidosis, produced by diabetes, which creases the production of lactic acid by the body. Use the Henderson-Hasselbach equation to predict the pH of e plasma under the next clinical conditions. Disease Metabolic acidosis Cause Production of acids by the metabolism 23 Experimental parameter Decrease the [HCO3¹] by 1, 10 and 20 mM pH A-/AH ratio

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8. Many diseases alter the ionic composition of the plasma, such as metabolic acidosis, produced by diabetes, which
increases the production of lactic acid by the body. Use the Henderson-Hasselbach equation to predict the pH of
the plasma under the next clinical conditions.
23
Disease
Cause
Experimental parameter
pH
A-/AH ratio
Decrease the [HCO;"]
by the metabolism by 1, 10 and 20 mM
Metabolic acidosis
Production of acids
Increase the [CO2] 5,10
Respiratory
Acidosis
Decrease in the
elimination of CO2
and 20%
Increase the [HCO;'] by
1, 10 and 20 mM
Metabolic alkalosis
Decrease in the
elimination of
НСО
Respiratory
Increase in the
Decrease the [CO2] 5,10
alkalosis
elimination of CO2
and 20%
Table 6. Prediction of the pH of the plasma in different medical conditions
Normal values: [HCO;']= 24 mM, [H2CO;]= 2.24 mM||
Note:
H,CO; exists in a chemical equilibrium with CO,
CO,+ H,O= H2CO3
[H;CO;]/[CO2] = 1.7 e³
Transcribed Image Text:8. Many diseases alter the ionic composition of the plasma, such as metabolic acidosis, produced by diabetes, which increases the production of lactic acid by the body. Use the Henderson-Hasselbach equation to predict the pH of the plasma under the next clinical conditions. 23 Disease Cause Experimental parameter pH A-/AH ratio Decrease the [HCO;"] by the metabolism by 1, 10 and 20 mM Metabolic acidosis Production of acids Increase the [CO2] 5,10 Respiratory Acidosis Decrease in the elimination of CO2 and 20% Increase the [HCO;'] by 1, 10 and 20 mM Metabolic alkalosis Decrease in the elimination of НСО Respiratory Increase in the Decrease the [CO2] 5,10 alkalosis elimination of CO2 and 20% Table 6. Prediction of the pH of the plasma in different medical conditions Normal values: [HCO;']= 24 mM, [H2CO;]= 2.24 mM|| Note: H,CO; exists in a chemical equilibrium with CO, CO,+ H,O= H2CO3 [H;CO;]/[CO2] = 1.7 e³
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