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I, O 1. CH3Li 2. H₂O

I, O 1. CH3Li 2. H₂O

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Predict the major product of this reaction. Be sure to include the key model that predicts the stereochemistry. Will the product be the threo or syn isomer? 

The image depicts a chemical reaction involving an aromatic ketone with an adjacent chiral center. The structure features a phenyl group attached to a ketone, with a tertiary butyl group and a hydrogen atom forming the chiral center. ### Chemical Structure: - **Left Side**: A tertiary butyl group (three methyl groups attached to a central carbon). - **Chiral Center**: A wedge bond to hydrogen indicates the stereochemistry. - **Ketone Group**: A carbon-oxygen double bond directly bonded to the phenyl ring. - **Phenyl Ring**: A six-carbon aromatic ring. ### Reaction Process: 1. **Reagent 1**: Methyl lithium (\( \text{CH}_3\text{Li} \)) 2. **Reagent 2**: Water (\( \text{H}_2\text{O} \)) ### Reaction Explanation: - **Step 1**: The compound reacts with methyl lithium, a strong nucleophile and base, which likely adds a methyl group to the carbonyl carbon and forms an alkoxide intermediate. - **Step 2**: The addition of water results in the protonation of the alkoxide to form an alcohol. This reaction illustrates nucleophilic addition to a carbonyl compound, a fundamental concept in organic chemistry.
Transcribed Image Text:The image depicts a chemical reaction involving an aromatic ketone with an adjacent chiral center. The structure features a phenyl group attached to a ketone, with a tertiary butyl group and a hydrogen atom forming the chiral center. ### Chemical Structure: - **Left Side**: A tertiary butyl group (three methyl groups attached to a central carbon). - **Chiral Center**: A wedge bond to hydrogen indicates the stereochemistry. - **Ketone Group**: A carbon-oxygen double bond directly bonded to the phenyl ring. - **Phenyl Ring**: A six-carbon aromatic ring. ### Reaction Process: 1. **Reagent 1**: Methyl lithium (\( \text{CH}_3\text{Li} \)) 2. **Reagent 2**: Water (\( \text{H}_2\text{O} \)) ### Reaction Explanation: - **Step 1**: The compound reacts with methyl lithium, a strong nucleophile and base, which likely adds a methyl group to the carbonyl carbon and forms an alkoxide intermediate. - **Step 2**: The addition of water results in the protonation of the alkoxide to form an alcohol. This reaction illustrates nucleophilic addition to a carbonyl compound, a fundamental concept in organic chemistry.
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