(i) Describe two methods you could use to synthesise your tert-BuLi. Include in your answer any important chemical and physical features associated with the procedures.

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Chapter1: Chemical Foundations
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(i)
Describe two methods you could use to synthesise your tert-BuLi. Include in your answer
any important chemical and physical features associated with the procedures.
Transcribed Image Text:(i) Describe two methods you could use to synthesise your tert-BuLi. Include in your answer any important chemical and physical features associated with the procedures.
Question 8:
In 1995 Prof. Steve Davies and his co-workers described the use of the lithiated chiral amine,
lithium (S)-(a-methylbenzyl)allylamide, in the highly enantioselective formation of B-amino acids
and B-lactams. You want to make use of this amide in your own research project to make a new B-
amino acid based antibiotic. After discussion with your supervisor you develop a research plan
which involves three stages:
you have to synthesise the chiral lithium anmide from the amine and tert-BuLi
whoops! you have to make your own tert-BuLi because it will take 9 months for a solution
to come from the UK and there is no time to waste.
finally, you have to do the conjugate asymmetric addition reaction with an a.ß unsaturated
ester.
(S)-(a-methylbenzyl)allylamine
Transcribed Image Text:Question 8: In 1995 Prof. Steve Davies and his co-workers described the use of the lithiated chiral amine, lithium (S)-(a-methylbenzyl)allylamide, in the highly enantioselective formation of B-amino acids and B-lactams. You want to make use of this amide in your own research project to make a new B- amino acid based antibiotic. After discussion with your supervisor you develop a research plan which involves three stages: you have to synthesise the chiral lithium anmide from the amine and tert-BuLi whoops! you have to make your own tert-BuLi because it will take 9 months for a solution to come from the UK and there is no time to waste. finally, you have to do the conjugate asymmetric addition reaction with an a.ß unsaturated ester. (S)-(a-methylbenzyl)allylamine
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