I arther: Chair conformers Monosubstituted rings The A-value for methyl, ethyl, isopropyl, and t-butyl substitution on a cyclohexane ring are 7.1kJ/mol, 7.3 kJ/mol, 9.0kJ/mol, and 18.8 kJ/mol, respectively.. Me Me 1. Et 95:5 95:5 Bu Bu 97:3 9995:5 Build the molecules and use your model to explain why the increased size of the substituent doe- not have a dramatic effect until you reach t-butyl. In other words, is it possible for the first three substituents (methyl, ethyl, and isopropyl) to achieve conformation in which 1,3-diaxial interactions are minimized? has -value: 0 9kJ/mol. Build the molecule in order to deterr

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I arther:
Chair conformers
Monosubstituted rings
The A-value for methyl, ethyl, isopropyl, and t-butyl substitution on a cyclohexane ring are
7.1kJ/mol, 7.3 kJ/mol, 9.0kJ/mol, and 18.8 kJ/mol, respectively..
Me
Me
1.
Et
95:5
95:5
Bu
Bu
97:3
9995:5
Build the molecules and use your model to explain why the increased size of the substituent doe-
not have a dramatic effect until you reach t-butyl. In other words, is it possible for the first three
substituents (methyl, ethyl, and isopropyl) to achieve conformation in which 1,3-diaxial
interactions are minimized?
mlugiest bn
todte
has
-value: 0 9k.J/mol. Build the molecule in order to deterr
Transcribed Image Text:I arther: Chair conformers Monosubstituted rings The A-value for methyl, ethyl, isopropyl, and t-butyl substitution on a cyclohexane ring are 7.1kJ/mol, 7.3 kJ/mol, 9.0kJ/mol, and 18.8 kJ/mol, respectively.. Me Me 1. Et 95:5 95:5 Bu Bu 97:3 9995:5 Build the molecules and use your model to explain why the increased size of the substituent doe- not have a dramatic effect until you reach t-butyl. In other words, is it possible for the first three substituents (methyl, ethyl, and isopropyl) to achieve conformation in which 1,3-diaxial interactions are minimized? mlugiest bn todte has -value: 0 9k.J/mol. Build the molecule in order to deterr
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