I 11 ||| IV III-8 III-7 III-3 III-1 1 2 3 1,2 2,2 2,2 III-5 1,2 2,2 1,2 2,2 4 5 1,2 2,2 6 (7 1,2 1,2 The pedigree above shows the pattern of inheritance of a vision disorder called Leber congenital amaurosis, which is due to mutations in a gene on chromosome 19 (filled symbols show affected individuals). Identification of the gene hinged on mapping it to a precise chromosomal location. Results of a small part of that mapping effort are shown above, analyzing linkage between a SNP marker on chr. 19 and the vision disorder in this family. The numbers below each person's pedigree symbol show what alleles they have for this SNP marker. Which individual in generation III has inherited a recombinant chromosome? 8 1,2 ? 2,2 1,2

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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8,9

1
||
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IV
III-8
III-7
III-3
III-1
III-5
1,2
The pedigree above shows the pattern of inheritance of a vision disorder called
Leber congenital amaurosis, which is due to mutations in a gene on chromosome
19 (filled symbols show affected individuals). Identification of the gene hinged
on mapping it to a precise chromosomal location. Results of a small part of that
mapping effort are shown above, analyzing linkage between a SNP marker on
chr. 19 and the vision disorder in this family. The numbers below each person's
pedigree symbol show what alleles they have for this SNP marker.
Which individual in generation III has inherited a recombinant chromosome?
III-2
2,2
1,2 2,2
1 2 3 4
5 6
(7
1,2 2,2 2,2 1,2 2,2 1,2 1,2
8
1,2 2,2
?
1,2
Transcribed Image Text:1 || ||| IV III-8 III-7 III-3 III-1 III-5 1,2 The pedigree above shows the pattern of inheritance of a vision disorder called Leber congenital amaurosis, which is due to mutations in a gene on chromosome 19 (filled symbols show affected individuals). Identification of the gene hinged on mapping it to a precise chromosomal location. Results of a small part of that mapping effort are shown above, analyzing linkage between a SNP marker on chr. 19 and the vision disorder in this family. The numbers below each person's pedigree symbol show what alleles they have for this SNP marker. Which individual in generation III has inherited a recombinant chromosome? III-2 2,2 1,2 2,2 1 2 3 4 5 6 (7 1,2 2,2 2,2 1,2 2,2 1,2 1,2 8 1,2 2,2 ? 1,2
SNP A SNP B
Results of ASO (antisense oligonucleotide) genotyping for two SNP markers are
shown here for individual III-1 in the pedigree provided for Question 8. Orange
indicates the presence of a hybridization signal and white indicates no
hybridization. Which of these markers could be the one informing the SNP
genotype designation "1,2" for individual III-1?
SNP A
Could be either
SNP B
Transcribed Image Text:SNP A SNP B Results of ASO (antisense oligonucleotide) genotyping for two SNP markers are shown here for individual III-1 in the pedigree provided for Question 8. Orange indicates the presence of a hybridization signal and white indicates no hybridization. Which of these markers could be the one informing the SNP genotype designation "1,2" for individual III-1? SNP A Could be either SNP B
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When two DNA molecules interact with one another, they recombine to form a new DNA molecule.

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