Hypertension A pilot study of a new antihypertensive agent is performed for the purpose of planning a larger study. Five patients who have a mean DBP of at least 95 mm Hg are recruited for the study and are kept on the agent for 1 month. Aft month the observed mean decline in DBP in these five patients is 4.9 mm Hg with a standard deviation of 8 mm Hg. USE SALT (a) If = true mean difference in DBP between baseline and 1 month, then how many patients would be needed to have a 90% chance of detecting a significant change in DBP over 1 month using a one-tailed test with a significance level of 5%? Assume that the true mean and standard deviation of the DBP difference were the same as observed in the pilot study. (Round your answer up to the next whole number.) ✔ patients 23 (b) Suppose we conduct a study of the preceding hypothesis based on 21 participants. What the probability we will be able to reject Housing one-sided test at the 5% level if the true mean and standard deviation of the DBP difference are the same as in the pilot study? (Round your answer to four decimal places.) 0.8335 x

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