Hypertension A doctor diagnoses a patient as hypertensive and prescribes an antihypertensive medication To assess the clinical status of the patient, the doctor takes n replicate blood-pressure measurements before the patient starts the drug (baseline) and n replicate blood-pressure measurements 4 weeks after starting the drug (follow-up). She uses the average of the n replicates at baseline minus the average of the n replicates at follow-up to assess the clini- cal status of the patient. She knows, from previous clinical experience with the drug, that the mean diastolic blood pressure (DBP) change over a 4-week period over a large number of patients after starting the drug is 5.0 mm Hg of age. Also, let us assume that the average SBP for a 50-year-old woman is 125 mm Hg, with a standard deviation of 15 mm Hg, and that SBP is normally distributed. 5.71 What proportion of 50-year-old women is hyperten- sive, if hypertension is defined as SBP 2 140 mm Hg? From previous clinical trials, it is estimated that for every 10 lbs. of weight loss there is, on average, a corresponding reduction in mean SBP of 3 mm Hg.

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