Huntington's Disease is an autosomal dominant disorder caused by trinucleotide repeat expansion. Huntington's disease gets progressively more severe with each generation because of these expanding repeats. What mechanism is responsible for these expanding repeats? O a. nonhomologous recombination O b. strand slippage O c. none of the above O d. Insertions O e. frameshift mutation

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
8
question Completion Status:
Oc. None of the above
O d. Reverse Genetics
O e. Epigenetics
QUESTION 8
Huntington's Disease is an autosomal dominant disorder caused by trinucleotide repeat expansion. Huntington's disease gets progressively more severe
with each generation because of these expanding repeats. What mechanism is responsible for these expanding repeats?
O a. nonhomologous recombination
O b. strand slippage
O c. none of the above
O d. Insertions
O e. frameshift mutation
QUESTION 9
In a lab, researchers induced a mutation to the Gal3 gene in yeast. The original sequence of the gene is show below:
5 ATGAATACAAACGTTCCAATATTCAGTTCTCCGGTCAGAGATTTACCAAGGTCTTTCGAA 3¹
3
TACTTATGTTTGCAAGGTTATAAGTCAAGAGGCCAGTCTCTAAACGGTTCCAGAAAGCTT 5¹
The modified sequence is shown below, with the mutation highlighted in bold:
3¹
5'
ATGAATACATAACGTTCCAATATTCAGTTCTCCGGTCAGAGATTTACCAAGGTCTTTCGAA
3 TACTTATGTATTGCAAGGTTATAAGTCAAGAGGCCAGTCTCTAAACGGTTCCAGAAAGCTT 5'
02: What effect will this mutation have on Gal1 expression?
O There will be no effect
Click Save and Submit to save and submit. Click Save All Answers to save all answers,
Transcribed Image Text:question Completion Status: Oc. None of the above O d. Reverse Genetics O e. Epigenetics QUESTION 8 Huntington's Disease is an autosomal dominant disorder caused by trinucleotide repeat expansion. Huntington's disease gets progressively more severe with each generation because of these expanding repeats. What mechanism is responsible for these expanding repeats? O a. nonhomologous recombination O b. strand slippage O c. none of the above O d. Insertions O e. frameshift mutation QUESTION 9 In a lab, researchers induced a mutation to the Gal3 gene in yeast. The original sequence of the gene is show below: 5 ATGAATACAAACGTTCCAATATTCAGTTCTCCGGTCAGAGATTTACCAAGGTCTTTCGAA 3¹ 3 TACTTATGTTTGCAAGGTTATAAGTCAAGAGGCCAGTCTCTAAACGGTTCCAGAAAGCTT 5¹ The modified sequence is shown below, with the mutation highlighted in bold: 3¹ 5' ATGAATACATAACGTTCCAATATTCAGTTCTCCGGTCAGAGATTTACCAAGGTCTTTCGAA 3 TACTTATGTATTGCAAGGTTATAAGTCAAGAGGCCAGTCTCTAAACGGTTCCAGAAAGCTT 5' 02: What effect will this mutation have on Gal1 expression? O There will be no effect Click Save and Submit to save and submit. Click Save All Answers to save all answers,
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