Human papilloma virus (HPV) is present in greater than 90% of cervical cancers. HPV encodes two proteins, E6 and E7, that are potent contributors to cancer development. E7 disables RB; E6 binds to p53 and targets it for degradation. Discuss how E6 and E7 might contribute to the development of the cancerous state in infected cells.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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5. Human papilloma virus (HPV) is present in greater than 90% of cervical cancers. HPV
encodes two proteins, E6 and E7, that are potent contributors to cancer development. E7
disables RB; E6 binds to p53 and targets it for degradation. Discuss how E6 and E7
might contribute to the development of the cancerous state in infected cells.
Transcribed Image Text:5. Human papilloma virus (HPV) is present in greater than 90% of cervical cancers. HPV encodes two proteins, E6 and E7, that are potent contributors to cancer development. E7 disables RB; E6 binds to p53 and targets it for degradation. Discuss how E6 and E7 might contribute to the development of the cancerous state in infected cells.
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