How will increasing the particle size of the column packing in an HPLC column affect the terms of the van Deemter equation? A, B, and C are increased. A is increased; C is decreased; B is unchanged. B and A are increased; C is decreased. B is unchanged; A and C are increased. O A is increased; B and C are unchanged.
How will increasing the particle size of the column packing in an HPLC column affect the terms of the van Deemter equation? A, B, and C are increased. A is increased; C is decreased; B is unchanged. B and A are increased; C is decreased. B is unchanged; A and C are increased. O A is increased; B and C are unchanged.
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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
Transcribed Image Text:**Question:**
How will increasing the particle size of the column packing in an HPLC column affect the terms of the van Deemter equation?
**Answer Options:**
- A. A, B, and C are increased.
- B. A is increased; C is decreased; B is unchanged.
- C. B and A are increased; C is decreased.
- D. B is unchanged; A and C are increased.
- E. A is increased; B and C are unchanged.
**Explanation:**
In High-Performance Liquid Chromatography (HPLC), the van Deemter equation is used to describe the different factors affecting the efficiency of a chromatographic column. The terms A, B, and C in the equation represent different sources of band broadening:
- A: Eddy diffusion
- B: Longitudinal diffusion
- C: Mass transfer
Increasing the particle size in the column packing generally impacts these factors and subsequently affects the separation efficiency of the column.
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