How manipulation of protonation state of compounds influence solubility in organic and aqueous solvents? (use reactions to support)
The solubility of a compound in different solvents is an important property that can be influenced by a number of factors, including its protonation state. Protonation or deprotonation can alter the charge and polarity of a compound, which in turn can affect its ability to interact with solvent molecules through hydrogen bonding and other interactions. In this answer, we will explore how the manipulation of protonation state can impact the solubility of compounds in both organic and aqueous solvents, and provide examples of reactions that illustrate these effects.
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