How is synthesis and degradation of fructose-2,6-bisphosphate achieved?
Fru-2,6-P2, or fructose 2,6-bisphosphate, is a metabolite that regulates glycolysis and gluconeogenesis by allosterically affecting the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1). The bifunctional enzyme phosphofructokinase 2/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) synthesizes and degrades fru-2,6-P2. Fru-2,6-P2 is made by a bifunctional enzyme that contains both PFK-2 and FBPase-2, which is dephosphorylated, allowing the PFK-2 part to phosphorylate fructose 6-phosphate with ATP. The phosphorylation of the bifunctional enzyme FBPase-2 catalyzes the breakdown of Fru-2,6-P2, allowing it to dephosphorylate fructose 2,6-bisphosphate to create fructose 6-phosphate and Pi.
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