Same question but two different sections How does the signaling cascade initiated by activation of the Gas protein enter the nucleus to trigger the transcription ofcyclic AMP responsive genes?O A. Phosphorylated CREB is transported across the nuclear envelope in COPIIl coated vesicles.B. CAMP enters the nucleus through nuclear pores.C. Gas diffuses into the nucleus to bind and activate its nuclear receptor.O D. Activated PKA enters the nucleus through nuclear pores. A modification is made in the Gas (G alpha s) signaling pathway by the process of evolution. This modification results in negativefeedback within the Gas pathway. Which of the following modifications would result in negative feedback that would attenuate(decrease) the resulting signal while the ligand activating the pathway is present?A. The G-protein coupled receptor that activates Gas is endocytosed and degraded.B. A target gene is transcribed that encodes for phosphodiesterase.C. Adenylyl cyclase activates PKAO D. Active PKA inhibits adenylyl cyclase.

Answered: How does the signaling cascade…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Same question but two different sections

How does the signaling cascade initiated by activation of the Gas protein enter the nucleus to trigger the transcription of
cyclic AMP responsive genes?
O A. Phosphorylated CREB is transported across the nuclear envelope in COPIIl coated vesicles.
B. CAMP enters the nucleus through nuclear pores.
C. Gas diffuses into the nucleus to bind and activate its nuclear receptor.
O D. Activated PKA enters the nucleus through nuclear pores.

A modification is made in the Gas (G alpha s) signaling pathway by the process of evolution. This modification results in negative
feedback within the Gas pathway. Which of the following modifications would result in negative feedback that would attenuate
(decrease) the resulting signal while the ligand activating the pathway is present?
A. The G-protein coupled receptor that activates Gas is endocytosed and degraded.
B. A target gene is transcribed that encodes for phosphodiesterase.
C. Adenylyl cyclase activates PKA
O D. Active PKA inhibits adenylyl cyclase.

Expert Solution

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G_s alpha subunit (G_sα) is a part of heterotrimeric G protein associated with G-protein coupled receptor (GPCR). Heterotrimeric G protein contains three subunits- α subunit, β subunit, and γ subunit. G-proteins are involved in intracellular signaling pathways such as the MAPK, PI3K, cAMP/PKA pathway.

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