How does proofreading increase the accuracy of genome replication? a. The DNA polymerase discriminates against incorrec nucleotides when these first become bound to the enzyme. b. The 5' 3' exonuclease activity of the DNA polymerase removes a nucleotide that has been incorrectly added to the end of the polynucleotide being synthesized. c. When the 3'-terminal nucleotide is not base-paired to the template DNA, it is removed by the exonuclease activity of the DNA polymerase. d. All of the above.

Database System Concepts
7th Edition
ISBN:9780078022159
Author:Abraham Silberschatz Professor, Henry F. Korth, S. Sudarshan
Publisher:Abraham Silberschatz Professor, Henry F. Korth, S. Sudarshan
Chapter1: Introduction
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How does proofreading increase the accuracy of
genome replication?
a. The DNA polymerase discriminates against incorrec
nucleotides when these first become bound to
the enzyme.
b. The 5' 3' exonuclease activity of the DNA
polymerase removes a nucleotide that has been
incorrectly added to the end of the polynucleotide
being synthesized.
c. When the 3'-terminal nucleotide is not base-paired
to the template DNA, it is removed by the
exonuclease activity of the DNA polymerase.
d. All of the above.
Transcribed Image Text:How does proofreading increase the accuracy of genome replication? a. The DNA polymerase discriminates against incorrec nucleotides when these first become bound to the enzyme. b. The 5' 3' exonuclease activity of the DNA polymerase removes a nucleotide that has been incorrectly added to the end of the polynucleotide being synthesized. c. When the 3'-terminal nucleotide is not base-paired to the template DNA, it is removed by the exonuclease activity of the DNA polymerase. d. All of the above.
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