how does chlorambucil react with dna? 1. identify nucleophile and electrophile
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
![how does chlorambucil react with dna?
1. identify nucleophile and electrophile
2. use curved arrows to show bonds breaking
and forming
3.show carbocation intermediates that can
form
4. identify more stable intermediate
5. draw structure of product
HOO0
CI
N'
CI
O Na
chlorambucil (aka Leukeran)
treatment of
chronic leukemia](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fbd47a440-79c7-43e8-a4b8-a961bcbda2f3%2F865cb8c0-47c4-474b-bc44-0fe835d3f11a%2Fsmexr8_processed.png&w=3840&q=75)
Transcribed Image Text:how does chlorambucil react with dna?
1. identify nucleophile and electrophile
2. use curved arrows to show bonds breaking
and forming
3.show carbocation intermediates that can
form
4. identify more stable intermediate
5. draw structure of product
HOO0
CI
N'
CI
O Na
chlorambucil (aka Leukeran)
treatment of
chronic leukemia
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