how does chlorambucil react with dna? 1. identify nucleophile and electrophile

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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how does chlorambucil react with dna?
1. identify nucleophile and electrophile
2. use curved arrows to show bonds breaking
and forming
3.show carbocation intermediates that can
form
4. identify more stable intermediate
5. draw structure of product
HOO0
CI
N'
CI
O Na
chlorambucil (aka Leukeran)
treatment of
chronic leukemia
Transcribed Image Text:how does chlorambucil react with dna? 1. identify nucleophile and electrophile 2. use curved arrows to show bonds breaking and forming 3.show carbocation intermediates that can form 4. identify more stable intermediate 5. draw structure of product HOO0 CI N' CI O Na chlorambucil (aka Leukeran) treatment of chronic leukemia
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