How does ATP regulate the activity of PFK-1? ☐☐ ATP binds to PFK-1 at the catalytic site as a competitive inhibitor, decreasing PFK-1 activity. ATP binds to the allosteric site as an inhibitor, decreasing PFK-1 activity. ATP binds to the catalytic site as a substrate, increasing PFK-1 activity. ATP binds to the allosteric site as an activator, increasing PFK-1 activity.
How does ATP regulate the activity of PFK-1? ☐☐ ATP binds to PFK-1 at the catalytic site as a competitive inhibitor, decreasing PFK-1 activity. ATP binds to the allosteric site as an inhibitor, decreasing PFK-1 activity. ATP binds to the catalytic site as a substrate, increasing PFK-1 activity. ATP binds to the allosteric site as an activator, increasing PFK-1 activity.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:How does ATP regulate the activity of PFK-1?
ATP binds to PFK-1 at the catalytic site as a competitive inhibitor, decreasing PFK-1 activity.
ATP binds to the allosteric site as an inhibitor, decreasing PFK-1 activity.
ATP binds to the catalytic site as a substrate, increasing PFK-1 activity.
ATP binds to the allosteric site as an activator, increasing PFK-1 activity.
![The graph shows the effect of ATP on the allosteric enzyme phosphofructokinase-1 (PFK-1).
PFK-1 activity (% of Vmax)
100
80
60
40
20
0
Low
[ADP]
[ATP]
High
[ADP]
For a given concentration of fructose 6-phosphate, the PFK-1 activity increases with increasing concentrations of ATP, but there
is a point beyond which increasing the concentration of ATP inhibits the enzyme.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Ff153f65b-a5bd-400b-be2c-4cde890c9d0b%2Fcf8fdb2d-fb6f-415d-bf82-128963f6e5c9%2Fhtgne_processed.jpeg&w=3840&q=75)
Transcribed Image Text:The graph shows the effect of ATP on the allosteric enzyme phosphofructokinase-1 (PFK-1).
PFK-1 activity (% of Vmax)
100
80
60
40
20
0
Low
[ADP]
[ATP]
High
[ADP]
For a given concentration of fructose 6-phosphate, the PFK-1 activity increases with increasing concentrations of ATP, but there
is a point beyond which increasing the concentration of ATP inhibits the enzyme.
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