How does a positive inotropic agent decrease the duration of cardiac muscle contraction?
How does a positive inotropic agent decrease the duration of cardiac muscle contraction?
Cardiac muscle contraction occurs within the heart muscle when myosin protein binds with adenosine triphosphate, then slides the actin filament towards the sarcomere center
Inotropic agents are the medical drugs that either increase or decrease the rate of contraction of the heart.
The agent which are responsible for decreasing the duration of cardiac muscle contraction is called negative inotropes.The negative Inotropes are responsible for decreasing the contraction of heart muscles and heart rate. These drugs are used to treat hypertension, heart failure, and another includes abnormal heart rhythm and chest pain.
Negative inotropes involve beta-blockers, antiarrhythmic medicines, and one is calcium channel blockers.
Beta-blockers function on the adrenaline of beta receptors of the body. They are responsible for decreasing the propagation of nerve impulses to the heart, which ultimately causes a decrease in heart muscle contraction as the heart need not to work hard as it requires less oxygen and blood.
Calcium channel blocker is responsible for or slowing the heart muscle contraction by decreasing the rate of calcium ion flow in the heart muscle; this ultimately causes heart muscle relaxation, thereby decreasing the blood pressure.
Antiarrhythmic medicine also responsible for decreasing the electrical impulse conduction within the heart.
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