The average diameter of a RBC is 7.2micrometer and average diameter of spherical RBC is 6.7micrometer. The normal RBC has an average surface area of 136micrometer^2 and volume of 91micrometer^3. Without a calculator how do you estimate the surface area to volume ratio for the spherical RBC?
The shape that a normal Red Blood Cell (RBC) has is disk-shaped and biconcave that are thicker at the edges than in the middle portion of the cell.
Certain hereditary conditions and mutations lead to a disorder that causes the RBCs to have an abnormal shape.
Spherocytosis is one such inherited blood disorder that gives rise to spherical RBCs instead of the normal biconcave disk-shaped cells. The spherical shape makes the cells more fragile than a normal RBC. Thus causing an easy breakdown that leads to anemia.
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