How do chaperonins assist polypeptides to become fully functional proteins?

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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How do chaperonins assist polypeptides to become fully functional proteins? 

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Proteins are polypeptides consisting of unbranched polymers constructed from 22 standard α-amino acids. They have four levels of structural organization and undergo folding to attain functional specificity. These distinct structural levels are known as primary, secondary, tertiary and quarternary structures of a protein.

Protein folding is the physical process by which a polypeptide folds into its characteristic and functional three dimensional confirmation. The correct three-dimensional structure is essential for protein folding and function. Failure to fold into native structure produces inactive proteins.

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