How are B cells that are self-reactive in the lymph nodes are handled? How is it detected? Does it die by apoptosis? Who sent the signal?

An Illustrated Guide To Vet Med Term
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ISBN:9781305465763
Author:ROMICH
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Chapter15: Feed And Protect Me
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How are B cells that are self-reactive in the lymph nodes are handled? How is it detected? Does it die by apoptosis? Who sent the signal?

Notice I know they go through selections in bone marrow and primary lymphoid organs, I am asking specific for secondary lymph organs. Thank you!

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