Hereditary persistence of hemoglobin F is protective against red cell sickling. A man in his late twenties (27 years old) was hospitalized with Acute chest syndrome and a severe vaso-occlusive crisis. Physica! exams did not show any remarkable findings. These hypoxic episodes were explained by lab findings which showed the presence of abnormal haemoglobin S (HbS), indicative of Sickle Cell Disease. Besides it and the normal adult haemoglobin (HbA) was found also Fetal Haemoglobin (HbF) in high percentage. 1. What is the difference between HbA and HbF? 2. What is the mechanism of transforming HbF to HbA and in which age this transformation ends? 3. What is HbS and what's happen in patients with this haemoglobin abnormality? 4. Why in this patient the problems started so late in age? Is the presence of residual HbF protection in Sickle cell anemia or thalasemias? 5. Can this knowledge be used as a treatment for SCD?

Hereditary persistence of hemoglobin F is protective against red cell sickling. A man in his late twenties (27 years old) was hospitalized with Acute chest syndrome and a severe vaso-occlusive crisis. Physica! exams did not show any remarkable findings. These hypoxic episodes were explained by lab findings which showed the presence of abnormal haemoglobin S (HbS), indicative of Sickle Cell Disease. Besides it and the normal adult haemoglobin (HbA) was found also Fetal Haemoglobin (HbF) in high percentage. 1. What is the difference between HbA and HbF? 2. What is the mechanism of transforming HbF to HbA and in which age this transformation ends? 3. What is HbS and what's happen in patients with this haemoglobin abnormality? 4. Why in this patient the problems started so late in age? Is the presence of residual HbF protection in Sickle cell anemia or thalasemias? 5. Can this knowledge be used as a treatment for SCD?

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

See similar textbooks

Similar questions

Indicate whether the sentence is True or False ( please answer the questions from 4 to 7 ( 4, 5, 6 and 7 )
Select the best answer or answers from the choices given: Aerobic exercise results in all of the following except (a) more capillaries surrounding muscle fibers, (b) more mitochondria in muscle cells, (c) increased size and strength of existing muscle cells, (d) more myoglobin.
The _______________________ muscle of the human is homologous to the sternomastoid muscle of the pig.
Mr. TZ, 40 years old, was admitted to the internal medicine service where you worked, due to peptic ulcer (PU) that developed secondary to chronic alcoholism. You enter Mr. TZ's room and find the patient having a Grand mal (tonic-clonic) contraction.1. List five activities you can doNote: Putting an eirway in the patient's mouth in this situation is dangerous for the patient and their caregivers.The patient's seizures do not seem to go away and the patient appears cyanotic. Physician orders 5, 10 mg of diazepam to be given until the unconsciousness level of the patient passes.2. What is the reason for giving diazepam to TZ?3. What is status epilepticus?4. What should you pay attention to when giving intravenous diazem? (List 3 items)When the physician arrived, the TZ contractions7 still had not passed the level of unconsciousness. Dr. He said to do another 10 mg of diazem. It's been 15 minutes since you found it and the epileptic seizure still continues.5. What is the significance of…
Passive force in skeletal muscle fibers is generated by ______________________ the muscle.
Define gap junction
Matching between Column I and corresponding definition or function in column II ( please answer all of them ) : Ans Column I Column II Ca binds to calmodulin 1. Binds calcium in skeletal muscle cells Ca binds to troponin 2. Occurs in smooth muscles only Type II muscle fibers 3. Is the primary source of Ca that drives muscle contraction Troponin 4. depend on glycolysis as a source of energy H zone 5. Anchors thin filaments together Z line 6. sheath of connective tissue surrounds a bundle of muscle fibres Sarcomere 7. The region of thick filaments that has no overlap with thin filaments Actin and myosin 8. Is the functional unit of skeletal muscle Perimysium 9. Occurs in skeletal and cardiac muscles Sarcoplasmic reticulum 10. Generate the mechanical force of a muscle through…
Write the names of the numbered structures on the corresponding lines shown on the image below and add large arrows to the the diagram displaying the direction the nerve impulse will travel from dendrites to the muscle
Question 15 40. Identify the muscle indicated by tag #40. 41. Identify two actions of the muscle indicated by tag #40. 42. Identify the muscle indicated by tag # 42. 40 42 Question 16
A woman is having an extremely prolonged labor. From her anatomy andphysiology course, she remembers the role of Ca2+ in muscle contractionand asks the doctor to give her a Ca2+ injection to speed the delivery.Explain why the doctor would or would not do as she requests.
Label the following muscle.
For the initial 10-12 seconds of muscle contraction, the ATP is provided by__________________.