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H₂CO A. Br D. H3O+, heat G. NaH H H 1 OH = H H₂CO H B. OCH3 H H The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. H Br OCH3 H OCH₂ 2 H E. 1) EtMgBr; 2) H3O+ H. SOCI₂ F. 1) LIAIH4; 2) H3O+ I. PCC or DMP

H₂CO A. Br D. H3O+, heat G. NaH H H 1 OH = H H₂CO H B. OCH3 H H The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. H Br OCH3 H OCH₂ 2 H E. 1) EtMgBr; 2) H3O+ H. SOCI₂ F. 1) LIAIH4; 2) H3O+ I. PCC or DMP

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Propose an efficent synthesis.

Steroidal derivatives are important pharmacologically and biologically, and the search for new biologically active steroid analogues is ongoing. Propose a possible synthesis for the conversion of steroid 1 to steroid 2, an intermediate in the synthesis of pentacyclic steroids (Tetrahedron Lett. 2012, 53, 1859-1862). H₂CO A. Br D. H3O+, heat G. NaH MI H 1 OH H H₂CO OCH 3 B. H H Ill Br OIII. H The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. OCH 3 "111 I OCH 3 2 H E. 1) EtMgBr; 2) H3O+ H. SOCI₂ C. CI F. 1) LiAlH4; 2) H3O+ I. PCC or DMP
Transcribed Image Text:Steroidal derivatives are important pharmacologically and biologically, and the search for new biologically active steroid analogues is ongoing. Propose a possible synthesis for the conversion of steroid 1 to steroid 2, an intermediate in the synthesis of pentacyclic steroids (Tetrahedron Lett. 2012, 53, 1859-1862). H₂CO A. Br D. H3O+, heat G. NaH MI H 1 OH H H₂CO OCH 3 B. H H Ill Br OIII. H The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. OCH 3 "111 I OCH 3 2 H E. 1) EtMgBr; 2) H3O+ H. SOCI₂ C. CI F. 1) LiAlH4; 2) H3O+ I. PCC or DMP
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