HCI RC=N + R'OH R the Ritter reaction NHR'

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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The reaction of a nitrile with an alcohol in the presence of a strong acid forms an N-substituted amide. This reaction, known as the Ritter reaction, does
not work with primary alcohols.

a. Propose a mechanism for the Ritter reaction.
b. Why does the Ritter reaction not work with primary alcohols?
c. How does the Ritter reaction differ from the acid-catalyzed hydrolysis of a nitrile to form an amide?

HCI
RC=N + R'OH
R
the Ritter reaction
NHR'
Transcribed Image Text:HCI RC=N + R'OH R the Ritter reaction NHR'
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