Answered: H3C NH- lidocaine

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Question

Show how lidocaine, one of the most widely used injectable anesthetics, can be prepared from benzene and compounds containing no more than four
carbons.

Expert Solution

Step 1

Lidocaine preparation can be done from benzene in the following steps-

Step 1: Nitration reaction of Benzene in presence of HNO₃ and H₂SO₄.

Step 2: Reduction of nitro-product by using Palladium as a catalyst.

Step 2

Step 3: Further reacting product with acyl chloride as shown below.

Step 4: Sulphonation of the product in step 3 and followed by Friedel craft alkylation reaction in excess of CH₃Cl as shown below.

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