H2B НЗ Histone octamer нз 11 nm DNA H2A НА Linker region Н2В Н2А Globular domain One histone protein Amino terminal Nucleosome- tail 8 histone proteins + 146 or 147 base pairs of DNA (a) Nucleosomes showing core histone proteins сoге (b) Molecular model for nucleosome structure Histone octamer Nonhistone proteins Linker FIGURE 10.10 Nucleosome structure. (a) A nucleosome con- histone (H1) sists of 146 or 147 bp of DNA wrapped around an octamer of core histone proteins. (b) A model for the structure of a nucleosome as determined by X-ray crystallography. The drawing shows two views of a nucleosome Linker that are at right angles to each other. (c) The linker region of DNA connects adjacent nucleosomes. The linker histone H1 and nonhistone proteins also bind to this linker region. DNA (b): © Laguna Design/SPL/Science Source (C) Nucleosomes showing linker histones and nonhistone proteins CONCEPT CHECK: What is the diameter of a nucleosome?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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What is the diameter of a nucleosome?

H2B
НЗ
Histone octamer
нз
11 nm
DNA
H2A
НА
Linker region
Н2В
Н2А
Globular
domain
One
histone
protein
Amino
terminal
Nucleosome-
tail
8 histone proteins +
146 or 147 base
pairs of DNA
(a) Nucleosomes showing core histone proteins
сoге
(b) Molecular model for nucleosome structure
Histone
octamer
Nonhistone
proteins
Linker
FIGURE 10.10 Nucleosome structure. (a) A nucleosome con-
histone (H1)
sists of 146 or 147 bp of DNA wrapped around an octamer of core histone
proteins. (b) A model for the structure of a nucleosome as determined by
X-ray crystallography. The drawing shows two views of a nucleosome
Linker
that are at right angles to each other. (c) The linker region of DNA
connects adjacent nucleosomes. The linker histone H1 and nonhistone
proteins also bind to this linker region.
DNA
(b): © Laguna Design/SPL/Science Source
(C) Nucleosomes showing linker histones
and nonhistone proteins
CONCEPT CHECK: What is the diameter of a nucleosome?
Transcribed Image Text:H2B НЗ Histone octamer нз 11 nm DNA H2A НА Linker region Н2В Н2А Globular domain One histone protein Amino terminal Nucleosome- tail 8 histone proteins + 146 or 147 base pairs of DNA (a) Nucleosomes showing core histone proteins сoге (b) Molecular model for nucleosome structure Histone octamer Nonhistone proteins Linker FIGURE 10.10 Nucleosome structure. (a) A nucleosome con- histone (H1) sists of 146 or 147 bp of DNA wrapped around an octamer of core histone proteins. (b) A model for the structure of a nucleosome as determined by X-ray crystallography. The drawing shows two views of a nucleosome Linker that are at right angles to each other. (c) The linker region of DNA connects adjacent nucleosomes. The linker histone H1 and nonhistone proteins also bind to this linker region. DNA (b): © Laguna Design/SPL/Science Source (C) Nucleosomes showing linker histones and nonhistone proteins CONCEPT CHECK: What is the diameter of a nucleosome?
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