Glucokinase (hexokinase IV) Hexokinase I, II, or III All hexokinase isozymes (I-IV) Answer Bank will phosphorylate several hexoses including glucose when blood glucose levels fall below normál range, isozyme remains at maximum velocity Km is in the range of physiologic blood glucose levels plays an important role in liver regulation of blood glucose level subcellular localization is regulated by fructose 6-phosphate will be saturated by normal blood glucose concentrations not sensitive to inhibition by glucose 6-phosphate when blood glucose is low, will cause cells to trap glucose by phosphorylation
Glucokinase (hexokinase IV) Hexokinase I, II, or III All hexokinase isozymes (I-IV) Answer Bank will phosphorylate several hexoses including glucose when blood glucose levels fall below normál range, isozyme remains at maximum velocity Km is in the range of physiologic blood glucose levels plays an important role in liver regulation of blood glucose level subcellular localization is regulated by fructose 6-phosphate will be saturated by normal blood glucose concentrations not sensitive to inhibition by glucose 6-phosphate when blood glucose is low, will cause cells to trap glucose by phosphorylation
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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![Glucokinase (hexokinase IV)
Hexokinase I, II, or III
All hexokinase isozymes (I-IV)
Answer Bank
will phosphorylate several hexoses including gluCose
when blood glucose levels fall below normal range, isozyme remains at maximum velocity
K is in the range of physiologic blood.glucose levels
plays an important-role in liver regulation of blood glucose level
subcellular localization is regulated by fructose 6-phosphate
will be saturated by normal blood glucose concentrations
not sensitive to inhibition by glucose 6-phosphale
when blood glucose is low, will cause cells to trap.glucose by phosphorylation](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F509bb1ad-89de-469f-8337-c594eb062b6b%2F5d0b537e-c9f7-4515-82f6-a11f46700317%2Fvgow7xa_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Glucokinase (hexokinase IV)
Hexokinase I, II, or III
All hexokinase isozymes (I-IV)
Answer Bank
will phosphorylate several hexoses including gluCose
when blood glucose levels fall below normal range, isozyme remains at maximum velocity
K is in the range of physiologic blood.glucose levels
plays an important-role in liver regulation of blood glucose level
subcellular localization is regulated by fructose 6-phosphate
will be saturated by normal blood glucose concentrations
not sensitive to inhibition by glucose 6-phosphale
when blood glucose is low, will cause cells to trap.glucose by phosphorylation
![The presence of multiple hexokinase isozymes (I–IV) for the phosphorylation of glucose enables specific organs to regulate
carbohydrate metabolism in a unique way. Hexokinase IV, also called glucokinase, represented by the blue curve in the plot, is
the predominant isozyme in liver. Hexokinase IV has distinct kinetic properties from the other hexokinase isozymes, which are
represented by the red curve. Note the difference in the shapes of the curves within the physiological range of glucose
concentration (~4 to 6 mM).
O.8
0.6
glucokinase (hexokinase IV)
0.4
02 -F
8
10
12
14
Glucose concentration (mM)
Determine whether each phrase describes glucokinase, hexokinase isozymes I-III, or all hexokinase isozymes.
Note: Assume that the kinetic behavior of hexokinase isozymes in vivo is similar to in vitro.
Glucokinase (hexokinase IV)
Hexokinase I, II, or III
All hexokinase isozymes (I-IV)](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F509bb1ad-89de-469f-8337-c594eb062b6b%2F5d0b537e-c9f7-4515-82f6-a11f46700317%2F23ez23_processed.jpeg&w=3840&q=75)
Transcribed Image Text:The presence of multiple hexokinase isozymes (I–IV) for the phosphorylation of glucose enables specific organs to regulate
carbohydrate metabolism in a unique way. Hexokinase IV, also called glucokinase, represented by the blue curve in the plot, is
the predominant isozyme in liver. Hexokinase IV has distinct kinetic properties from the other hexokinase isozymes, which are
represented by the red curve. Note the difference in the shapes of the curves within the physiological range of glucose
concentration (~4 to 6 mM).
O.8
0.6
glucokinase (hexokinase IV)
0.4
02 -F
8
10
12
14
Glucose concentration (mM)
Determine whether each phrase describes glucokinase, hexokinase isozymes I-III, or all hexokinase isozymes.
Note: Assume that the kinetic behavior of hexokinase isozymes in vivo is similar to in vitro.
Glucokinase (hexokinase IV)
Hexokinase I, II, or III
All hexokinase isozymes (I-IV)
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