Given the partial structure below, add a substituent “X" to C-1 so that it satisfies the indicated stereochemical requirement: a. anti to A b. anti to C-3 c. gauche to A d. gauche to C-3 1 A

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**Question:**

Given the partial structure below, add a substituent “X” to C-1 so that it satisfies the indicated stereochemical requirement:

a. anti to A  
b. anti to C-3  
c. gauche to A  
d. gauche to C-3  

**Explanation:**

The partial structure provided is a cyclohexane chair conformation, a common conformation for six-membered ring structures. The provided diagram shows the following:

- A substituent labeled "A" is attached to carbon 1 (C-1).
- Carbon 3 (C-3) is labeled explicitly and identified as another point of interest for substitution.

Cyclohexane conformations are depicted with hydrogen atoms, and substituents can be placed in axial or equatorial positions. The terms "anti" and "gauche" refer to specific spatial relationships:

- "Anti" position means that the groups are on opposite planes (typically 180 degrees apart).
- "Gauche" position means that the groups are next to each other, either on the same plane or adjacent (typically 60 degrees apart).

**Diagram Analysis:**

The diagram shows a basic chair conformation with carbon atoms numbered, and a substituent (A) from axial position on C-1:

![Cyclohexane Partial Structure](cyclohexanepartialstructure.png)

Using this guide, the appropriate placement of a substituent “X” on C-1 can be determined to match the given stereochemical requirements: 

1. **(a) Anti to A**: Place X in the equatorial position at C-1.
2. **(b) Anti to C-3**: Since C-3 is axial, place X equatorial at C-1.
3. **(c) Gauche to A**: Place X in axial position at C-1.
4. **(d) Gauche to C-3**: Since C-3 is axial, place X axial at C-1.

Understanding these placements helps in establishing precise stereochemistry in cyclohexane derivatives, crucial for organic synthesis and reaction prediction.
Transcribed Image Text:**Question:** Given the partial structure below, add a substituent “X” to C-1 so that it satisfies the indicated stereochemical requirement: a. anti to A b. anti to C-3 c. gauche to A d. gauche to C-3 **Explanation:** The partial structure provided is a cyclohexane chair conformation, a common conformation for six-membered ring structures. The provided diagram shows the following: - A substituent labeled "A" is attached to carbon 1 (C-1). - Carbon 3 (C-3) is labeled explicitly and identified as another point of interest for substitution. Cyclohexane conformations are depicted with hydrogen atoms, and substituents can be placed in axial or equatorial positions. The terms "anti" and "gauche" refer to specific spatial relationships: - "Anti" position means that the groups are on opposite planes (typically 180 degrees apart). - "Gauche" position means that the groups are next to each other, either on the same plane or adjacent (typically 60 degrees apart). **Diagram Analysis:** The diagram shows a basic chair conformation with carbon atoms numbered, and a substituent (A) from axial position on C-1: ![Cyclohexane Partial Structure](cyclohexanepartialstructure.png) Using this guide, the appropriate placement of a substituent “X” on C-1 can be determined to match the given stereochemical requirements: 1. **(a) Anti to A**: Place X in the equatorial position at C-1. 2. **(b) Anti to C-3**: Since C-3 is axial, place X equatorial at C-1. 3. **(c) Gauche to A**: Place X in axial position at C-1. 4. **(d) Gauche to C-3**: Since C-3 is axial, place X axial at C-1. Understanding these placements helps in establishing precise stereochemistry in cyclohexane derivatives, crucial for organic synthesis and reaction prediction.
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