Given the following compounds: 1-bromopropane, 1-chloropropane, 2-chlorobutane, and 1-chloro-2-methylpropane Order them based on their reactivity against the SN2 reaction (decreasing). Will the substitution proceed faster with CH3O- or CH3S-? Reason for it.
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
Given the following compounds:
1-bromopropane, 1-chloropropane, 2-chlorobutane, and 1-chloro-2-methylpropane
Order them based on their reactivity against the SN2 reaction (decreasing). Will the substitution proceed faster with CH3O- or CH3S-? Reason for it.
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