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General Structure-Function Association for Different Benzodiazepine Modifications. e.g. CH, Methyl substituent shows the highest increase in activity and bulky substituents such as a phenyl group lead to loss of activity Triazolo analogs tend to show a significantly higher activity e.g. CH, Decisive effect on the activity e.g. OH CH, Substituent leads to an e.g. NO, CI Br decrease in activity Activity increase with e.g. F CI electron withdrawing Halogen substituents in ortho- position lead to significantly enhanced activity substituent * Substitutions at C-6, C-8, and C-9 lower the activity Substituents exhibit strong steric repulsion at the GABA, receptor " Phenyl ring at C-5 position seems to be the best option with only pyridyl remarkable activity derivatives showing

General Structure-Function Association for Different Benzodiazepine Modifications. e.g. CH, Methyl substituent shows the highest increase in activity and bulky substituents such as a phenyl group lead to loss of activity Triazolo analogs tend to show a significantly higher activity e.g. CH, Decisive effect on the activity e.g. OH CH, Substituent leads to an e.g. NO, CI Br decrease in activity Activity increase with e.g. F CI electron withdrawing Halogen substituents in ortho- position lead to significantly enhanced activity substituent * Substitutions at C-6, C-8, and C-9 lower the activity Substituents exhibit strong steric repulsion at the GABA, receptor " Phenyl ring at C-5 position seems to be the best option with only pyridyl remarkable activity derivatives showing

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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1.Activity electron substituent increase with withdrawing？what does it means？does it means when NO2 ，CI ，Br is attached on that ring will increase the activity or without NO2 ，CI ，Br is attached will be better？？ Please type！No hand writing！
General Structure-Function Association for Different Benzodiazepine Modifications. e.g. CH, Methyl substituent shows the highest increase in activity and bulky substituents such as a phenyl group lead to loss of activity Triazolo analogs tend to show a significantly higher activity e.g. CH, Decisive effect on the activity e.g. OH CH, Substituent leads to an e.g. NO, CI Br decrease in activity Activity increase with e.g. F CI electron withdrawing Halogen substituents in ortho- position lead to significantly enhanced activity substituent * Substitutions at C-6, C-8, and C-9 lower the activity Substituents exhibit steric strong repulsion at the GABA, receptor " Phenyl ring at C-5 position seems to be the best option with only pyridyl remarkable activity derivatives showing
Transcribed Image Text:General Structure-Function Association for Different Benzodiazepine Modifications. e.g. CH, Methyl substituent shows the highest increase in activity and bulky substituents such as a phenyl group lead to loss of activity Triazolo analogs tend to show a significantly higher activity e.g. CH, Decisive effect on the activity e.g. OH CH, Substituent leads to an e.g. NO, CI Br decrease in activity Activity increase with e.g. F CI electron withdrawing Halogen substituents in ortho- position lead to significantly enhanced activity substituent * Substitutions at C-6, C-8, and C-9 lower the activity Substituents exhibit steric strong repulsion at the GABA, receptor " Phenyl ring at C-5 position seems to be the best option with only pyridyl remarkable activity derivatives showing
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