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Gd(III) needs to be strongly chelated when used in medical imaging applications because the free ion can displace Ca(II) in protein active sites and disrupt biological function. What is the best atom to coordinate these metal ions from amino acids? A. Oxygen B. Nitrogen C. Sulfur D. Carbon

Gd(III) needs to be strongly chelated when used in medical imaging applications because the free ion can displace Ca(II) in protein active sites and disrupt biological function. What is the best atom to coordinate these metal ions from amino acids? A. Oxygen B. Nitrogen C. Sulfur D. Carbon

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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### Coordination of Gd(III) in Medical Imaging Applications **Background:** Gadolinium (Gd(III)) needs to be strongly chelated when used in medical imaging applications because the free ion can displace calcium ions (Ca(II)) in protein active sites, causing potential disruptions in biological functions. **Question:** To prevent such disruptions, which atom is the best to coordinate these metal ions from amino acids? **Options:** A. Oxygen B. Nitrogen C. Sulfur D. Carbon **Explanation:** When selecting an atom for coordination with metal ions in amino acids, it is crucial to consider the atom's ability to form strong and stable chelates with the metal ion in question. The coordination chemistry involved helps in maintaining the integrity and proper function of biological systems during imaging procedures.
Transcribed Image Text:### Coordination of Gd(III) in Medical Imaging Applications **Background:** Gadolinium (Gd(III)) needs to be strongly chelated when used in medical imaging applications because the free ion can displace calcium ions (Ca(II)) in protein active sites, causing potential disruptions in biological functions. **Question:** To prevent such disruptions, which atom is the best to coordinate these metal ions from amino acids? **Options:** A. Oxygen B. Nitrogen C. Sulfur D. Carbon **Explanation:** When selecting an atom for coordination with metal ions in amino acids, it is crucial to consider the atom's ability to form strong and stable chelates with the metal ion in question. The coordination chemistry involved helps in maintaining the integrity and proper function of biological systems during imaging procedures.
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