G) A mutation has occurred rendering the regulatory protein unable to recognize the operator sequence. What effect would this have on the expression of this operon? How would this impact the energetic demands on the cell? Justify your answer.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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Question 5
G) A mutation has occurred rendering the regulatory protein unable to recognize the operator
sequence. What effect would this have on the expression of this operon? How would this
impact the energetic demands on the cell? Justify your answer.
Info:
Remember that hexose kinase is an enzyme required for hexose metabolism, a process that takes a
6-carbon sugar and breaks it down into 2 pyruvate molecules.
You discover that rather than being hormonally regulated (as seen above in humans), hexose kinase
is part of an operon in prokaryotic organisms. This operon is known as the "hexose operon" and it
regulates expression of the complete set of enzymes needed to convert a hexose sugar into 2
pyruvate molecules.
Like the lac operon, the hexose operon is controlled by a separate regulatory protein under the control
of its own promoter (see the schematic of the operon below). The hexose regulatory protein is
sensitive to fatty acyl CoA levels. When all hexose fuel sources are depleted, the bacteria switch to
lipid metabolism and fatty acyl CoA levels increase. This turns expression of the hexose operon off.
+1
+1
Regulatory Gene
Pregulator
Poperon
Hexose Operon Genes
regulator promoter
operon promoter
Transcribed Image Text:Question 5 G) A mutation has occurred rendering the regulatory protein unable to recognize the operator sequence. What effect would this have on the expression of this operon? How would this impact the energetic demands on the cell? Justify your answer. Info: Remember that hexose kinase is an enzyme required for hexose metabolism, a process that takes a 6-carbon sugar and breaks it down into 2 pyruvate molecules. You discover that rather than being hormonally regulated (as seen above in humans), hexose kinase is part of an operon in prokaryotic organisms. This operon is known as the "hexose operon" and it regulates expression of the complete set of enzymes needed to convert a hexose sugar into 2 pyruvate molecules. Like the lac operon, the hexose operon is controlled by a separate regulatory protein under the control of its own promoter (see the schematic of the operon below). The hexose regulatory protein is sensitive to fatty acyl CoA levels. When all hexose fuel sources are depleted, the bacteria switch to lipid metabolism and fatty acyl CoA levels increase. This turns expression of the hexose operon off. +1 +1 Regulatory Gene Pregulator Poperon Hexose Operon Genes regulator promoter operon promoter
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