For this question, consider the following thiamine - catalyzed benzoin condensation of 2- pyridinecarbaldehyde. Draw the structure of the product that would form in the benzoin condensation shown above. Be sure to draw in any H atoms connected to heteroatoms.
For this question, consider the following thiamine - catalyzed benzoin condensation of 2- pyridinecarbaldehyde. Draw the structure of the product that would form in the benzoin condensation shown above. Be sure to draw in any H atoms connected to heteroatoms.
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:For this question, consider the following thiamine - catalyzed benzoin condensation of 2 -
pyridinecarbaldehyde. Draw the structure of the product that would form in the benzoin
condensation shown above. Be sure to draw in any H atoms connected to heteroatoms.
2
2-pyridinecarbaldehyde
H
Thiamine
H₂O, ethanol
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Step 1: Benzoin condensation
VIEWStep 2: Mechanism of the reaction- Formation of ylide from vitamin B1 or thiamine.
VIEWStep 3: Mechanism of the reaction-Formation of enamine nucleophile
VIEWStep 4: Mechanism of the reaction-The coupling between enamine and the aldehyde molecule.
VIEWStep 5: Mechanism of the reaction-Formation of the product and the regeneration of ylide.
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