For the below mating, what proportion of offspring will be blood type 0? H/h; A/i* h/h; A/i A) 1/4 B) 3/8 C) 5/8 D) 3/16 E) 9/16

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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**Genetics Problem: Blood Type Inheritance**

**Question:**  
For the below mating, what proportion of offspring will be blood type 0?

**Genotype Cross:**

- Parent 1: \(H/h; \, I^A/i\) 
- Parent 2: \(h/h; \, I^A/i\)

**Options:**
A) \( \frac{1}{4} \)  
B) \( \frac{3}{8} \)  
C) \( \frac{5}{8} \)  
D) \( \frac{3}{16} \)  
E) \( \frac{9}{16} \)  

**Explanation:**

This problem involves dihybrid crosses. The H/h and I genes represent alleles for blood type: 

- \(H/h\) denotes a gene influencing blood type expression.
- \(I^A/i\) denotes the ABO blood group alleles.

The task is to determine the proportion of the offspring with blood type O, which requires being homozygous recessive for the \(h\) allele (absence of H substance) and possessing the \(i/i\) genotype (O blood type).

The answer choices suggest the probability of inheriting these genotypes based on the given cross.
Transcribed Image Text:**Genetics Problem: Blood Type Inheritance** **Question:** For the below mating, what proportion of offspring will be blood type 0? **Genotype Cross:** - Parent 1: \(H/h; \, I^A/i\) - Parent 2: \(h/h; \, I^A/i\) **Options:** A) \( \frac{1}{4} \) B) \( \frac{3}{8} \) C) \( \frac{5}{8} \) D) \( \frac{3}{16} \) E) \( \frac{9}{16} \) **Explanation:** This problem involves dihybrid crosses. The H/h and I genes represent alleles for blood type: - \(H/h\) denotes a gene influencing blood type expression. - \(I^A/i\) denotes the ABO blood group alleles. The task is to determine the proportion of the offspring with blood type O, which requires being homozygous recessive for the \(h\) allele (absence of H substance) and possessing the \(i/i\) genotype (O blood type). The answer choices suggest the probability of inheriting these genotypes based on the given cross.
Expert Solution
Step 1

The H gene is important for the expression of H antigen which is vital for the expression of A and B antigens. H allele is dominant over h allele.

IA represents the A blood group which is dominant over the recessive i allele.

The cross is between Hh/ IAi and hh/ IA

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