Font Paragraph Styles Write Up Sheet for Multi-step Synthesis Experiment 1) Write the reaction scheme (starting material(s), reagents, expected product) for the complete multi-step synthesis of your target molecule. Solvents and catalysts should be included, though "work up" steps need not be shown. Br Br OH 10% (w/v) Br2 HO, TSOH OCH3 HOAC H3CO CH;OH H3CO H3CO Reflux 2) Classify the reaction involved in each step of your multi-step synthesis using one of the following terms: acylation alkylation electrophilic substitution nucleophilic addition oxidation reduction Step 1: Step 2: 3) What isolation technique (suction filtration, extraction, etc.) do you expect to use to isolate the product in each step. See problem 5 below, i e. literature melting point data, to assist with this assessment Step 1: Step 2:

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### Write-Up Sheet for Multi-step Synthesis Experiment

**1) Write the reaction scheme (starting material(s), reagents, expected product) for the complete multi-step synthesis of your target molecule. Solvents and catalysts should be included, though “work up” steps need not be shown.**

![Chemical Reaction Scheme]
- Starting Material: 
  - A benzene ring with a methoxy group (-OCH3) and a hydroxyl group (-OH) attached (starting material on the left).
- Step 1 Reagents: 
  - 10% (w/v) Bromine (Br2) in acetic acid (HOAC).
- Intermediate Product: 
  - A benzene ring with a methoxy group and two bromine atoms ortho to the methoxy group, one hydroxyl group para to the methoxy group, and one free carboxyl group (COOH).
- Step 2 Reagents: 
  - Tosic acid (TsOH) in methanol (CH3OH) with reflux conditions.
- Final Product: 
  - A benzene ring with a methoxy group ortho to a carboxyl group (COOH) and a bromine atom para to the carboxyl group, and one free hydroxyl group para to the methoxy group.

**2) Classify the reaction involved in each step of your multi-step synthesis using one of the following terms:**
*acylation | alkylation | electrophilic substitution | nucleophilic addition | oxidation | reduction*

- Step 1: ___________________________
- Step 2: ___________________________

**3) What isolation technique (suction filtration, extraction, etc.) do you expect to use to isolate the product in each step. See problem 5 below, i.e., literature melting point data, to assist with this assessment**

- Step 1: ___________________________
- Step 2: ___________________________

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This document is designed to guide students through a multi-step synthesis experiment. It involves identifying and classifying the chemical reactions in each step and selecting appropriate isolation techniques. It provides a clear and structured approach for educational purposes in a chemistry laboratory course.
Transcribed Image Text:--- ### Write-Up Sheet for Multi-step Synthesis Experiment **1) Write the reaction scheme (starting material(s), reagents, expected product) for the complete multi-step synthesis of your target molecule. Solvents and catalysts should be included, though “work up” steps need not be shown.** ![Chemical Reaction Scheme] - Starting Material: - A benzene ring with a methoxy group (-OCH3) and a hydroxyl group (-OH) attached (starting material on the left). - Step 1 Reagents: - 10% (w/v) Bromine (Br2) in acetic acid (HOAC). - Intermediate Product: - A benzene ring with a methoxy group and two bromine atoms ortho to the methoxy group, one hydroxyl group para to the methoxy group, and one free carboxyl group (COOH). - Step 2 Reagents: - Tosic acid (TsOH) in methanol (CH3OH) with reflux conditions. - Final Product: - A benzene ring with a methoxy group ortho to a carboxyl group (COOH) and a bromine atom para to the carboxyl group, and one free hydroxyl group para to the methoxy group. **2) Classify the reaction involved in each step of your multi-step synthesis using one of the following terms:** *acylation | alkylation | electrophilic substitution | nucleophilic addition | oxidation | reduction* - Step 1: ___________________________ - Step 2: ___________________________ **3) What isolation technique (suction filtration, extraction, etc.) do you expect to use to isolate the product in each step. See problem 5 below, i.e., literature melting point data, to assist with this assessment** - Step 1: ___________________________ - Step 2: ___________________________ --- This document is designed to guide students through a multi-step synthesis experiment. It involves identifying and classifying the chemical reactions in each step and selecting appropriate isolation techniques. It provides a clear and structured approach for educational purposes in a chemistry laboratory course.
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