FIGURE 24.6 Helicobacter pylori Pathogenesis Neutrophils are common in the early inflammatory response to H. pylori. Lymphocytes and other cells appear later. Urease CO(NH2)2 + H,0 CO2 + 2 NH3 How does urease allow Urea Ammonia H. pylori to live in the stomach? Helicobacter pylori Bacteria 2 Thinning of mucus layer due to mucosal damage Acidic environment of stomach penetrate and multiply in mucus layer Epithelium destroyed Mucus layer Mucus- Ulcer secreting cell mar Epithelium lining the stomach Basement membrane Connective Red blood cell Neutrophil Plasma Lymphocyte cell tissue Dilated capillary Capillary- Red blood cell- Inflammatory response Bacterial cells use their flagella to penetrate the mucus layer, and then attach to the mucus- secreting epithelium or multiply adjacent to it. Helicobacter survives the acidic environment of the stomach by secreting urease, which breaks urea into carbon dioxide and ammonia. Bacterial toxins and inflammation damage epithelial cells, decreasing mucus production; acidic stomach juices damage the exposed tissue, causing a peptic ulcer. Ammonia neutralizes stomach acid.
FIGURE 24.6 Helicobacter pylori Pathogenesis Neutrophils are common in the early inflammatory response to H. pylori. Lymphocytes and other cells appear later. Urease CO(NH2)2 + H,0 CO2 + 2 NH3 How does urease allow Urea Ammonia H. pylori to live in the stomach? Helicobacter pylori Bacteria 2 Thinning of mucus layer due to mucosal damage Acidic environment of stomach penetrate and multiply in mucus layer Epithelium destroyed Mucus layer Mucus- Ulcer secreting cell mar Epithelium lining the stomach Basement membrane Connective Red blood cell Neutrophil Plasma Lymphocyte cell tissue Dilated capillary Capillary- Red blood cell- Inflammatory response Bacterial cells use their flagella to penetrate the mucus layer, and then attach to the mucus- secreting epithelium or multiply adjacent to it. Helicobacter survives the acidic environment of the stomach by secreting urease, which breaks urea into carbon dioxide and ammonia. Bacterial toxins and inflammation damage epithelial cells, decreasing mucus production; acidic stomach juices damage the exposed tissue, causing a peptic ulcer. Ammonia neutralizes stomach acid.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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How does urease allow H. pylori to live in the stomach?
Transcribed Image Text:FIGURE 24.6 Helicobacter pylori Pathogenesis
Neutrophils are common in the early inflammatory response to
H. pylori. Lymphocytes and other cells appear later.
Urease
CO(NH2)2 + H,0
CO2 + 2 NH3
How does urease allow
Urea
Ammonia
H. pylori to live in the stomach?
Helicobacter pylori
Bacteria
2
Thinning of mucus layer
due to mucosal damage
Acidic environment
of stomach
penetrate and
multiply in
mucus layer
Epithelium destroyed
Mucus layer
Mucus-
Ulcer
secreting cell
mar
Epithelium
lining the
stomach
Basement
membrane
Connective
Red blood cell
Neutrophil Plasma Lymphocyte
cell
tissue
Dilated capillary
Capillary-
Red blood cell-
Inflammatory response
Bacterial cells use their flagella
to penetrate the mucus layer,
and then attach to the mucus-
secreting epithelium or multiply
adjacent to it.
Helicobacter survives the acidic environment
of the stomach by secreting urease, which
breaks urea into carbon dioxide and ammonia.
Bacterial toxins and inflammation damage epithelial cells,
decreasing mucus production; acidic stomach juices
damage the exposed tissue, causing a peptic ulcer.
Ammonia neutralizes stomach acid.
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