Part 2 Bio Question 1 Figure 2 illustrates how Pitx1 transcription is regulated in different tissues. The center image is that of astickleback embryo. The drawings in the surrounding boxes show the Pitx1 gene region and activator proteinspresent in the jaw, pelvis, eye, or pituitary tissues. Note that for simplicity, we are only showing one activatormolecule present in a particular tissue. In reality, many activators are present in a particular tissue at any onetime. Activator molecules with specific shading can bind to switches with the same shading.1. List all the tissues shown in Figure 2 that express the Pitx1 gene. PART 2As you saw in the film, the presence or absence of pelvic spines in the stickleback fish is controlled by whetherthe Pitx1 gene is expressed in the pelvic tissue. However, the Pitx1 protein is actually important in building otherbody parts and is therefore expressed in multiple tissues at specific times.How is Pitx1 expressed in different tissues? The Pitx1 gene has multiple regulatory switches that control theexpression of the gene in different tissues: the pituitary, jaw, and pelvic tissues. Having multiple switchesenables Pitx1 to be used many times in different contexts and expands the versatility of that gene. Theseswitches are part of the DNA upstream of the Pitx1 coding region. Activators present in a particular tissue bindto a specific sequence on the DNA and turn Pitx1 on in the appropriate tissues. For example, in the cells thatdevelop into the pelvis there is a specific activator (activator 2) that binds in a sequence-specific manner to thepelvic switch to transcribe Pitx1 in that tissue. In the jaw, there is a different activator (activator 1) that binds toa different sequence called the jaw switch to turn on Pitx1 in the jaw tissue. However, Pitx1 is not transcribed inthe eyes because it does not have a sequence that can bind to activators present in the eyes. As you can see,while the DNA is the same in all cells of the body, the activators that are present differ from tissue to tissue. Byhaving multiple regulatory switches, Pitx1 can be used many times in different tissues to build specific body parts.JawPelvisActivator 1EyeAPituitary JawswitchPelvicswitchswitchFigure 2PituitaryswitchPitx1QOLOLOLOLOLOLJawswitchPelvicswitchActivator 2PituitaryswitchJawPelvicswitchswitchPituitaryActivator 3Pitx1LOLOLOLOLOLOUPituitary Jawswitch switchPitx1Activator 4PelvicswitchPitx1OLOLOLOLOLOU

Name: Part 2 Bio Question 1 Figure 2 illustrates how Pitx1 transcription is
Uploaded: 2024-03-20T06:42:55.000Z
Channel: Bartleby
Description: Part 2 Bio Question 1 Figure 2 illustrates how Pitx1 transcription is regulated in different tissues. The center image is that of astickleback embryo. The drawings in the surrounding boxes show the Pitx1 gene region and activator proteinspresent in t