Explain the basics of a disease involving a breakdown in the structure/function of a receptor and/or intracellular targets involved in a signal transduction pathway. Describe some of these diseases in the table below:
Explain the basics of a disease involving a breakdown in the structure/function of a receptor and/or intracellular targets involved in a signal transduction pathway. Describe some of these diseases in the table below:
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Explain the basics of a disease involving a breakdown in the structure/function of a receptor and/or intracellular targets involved in a signal transduction pathway. Describe some of these diseases in the table below:

Transcribed Image Text:Disease
Breakdown
Effects of Breakdown Leading to Disease
Familial hypercholesterolemia is caused by a
reduction or mutational defect in the LDL
receptor, which leads to inadequate hepatic
clearance of circulating LDL cholesterol
Defective particles. This leads to the formation of
or reduced atherosclerotic plaques in the arterial wall
which is responsible for early coronary heart
disease, stroke, and peripheral vascular
disease. Cholesterol also accumulates in
other areas including the skin, cornea, heart
valves, and other sites causing lesions
secondary to its deposition.
Familial
hypercholesteremia LDL
receptors
1
4
LO
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