Explain how the biosynthesis of fatty acids from carbohydrates works(starting with the ingestion of starch and ending with a fatty acid).

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Explain how the biosynthesis of fatty acids from carbohydrates works(starting with the ingestion of starch and ending with a fatty acid).

Expert Solution
Step 1

When the level of glucose is high in the body, the excess amount of Acetyl CoA produced by the glycolysis, can be converted into triglycerides, steroids, cholesterol and fatty acids. The process of formation of fatty acids from Acetyl CoA is known as Lipogenesis. It takes place in the cytoplasm of the liver (hepatocytes) and fat (adipocytes) cells. It is an anabolic process, consuming ATP.

Step 2

Lipogenesis starts with Acetyl CoA, which is created in the mitochondria and is taken to the cytoplasm. The transport of Acetyl CoA from mitochondria to cytoplasm is not easy. Hence, pyruvate is converted into both, Acetyl CoA and Oxaloacetate. They both combine to form Citrate, which has the ability to cross mitochondrial membrane. As soon as it enters into the cytoplasm, citrate dissociates back to form OAA and Acetyl CoA. 

  • OAA converts into Malate and further, into Pyruvate, which acts as a precursor for the next cycle of Lipogenesis. However, Acetyl CoA converts into Malonyl CoA with the help of the enzyme, Acetyl CoA Carboxylase (ACC). 
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