Explain how interference with mitotic structures or disruption of mitotic processes affects cell reproduction and ultimately the organism.
Explain how interference with mitotic structures or disruption of mitotic processes affects cell reproduction and ultimately the organism.
The term mitotic division refers to the process of cell division of somatic cells, which is the basis of growth and development in all eukaryotic organisms. It involves the duplication of chromosomes and the separation of chromatic material into two daughter cells.
Any disruption in the mechanism of mitotic cell division, either caused by mutations or any external factor, leads to erroneous mitotic division and results in diseases like cancer; several erroneous mechanisms like anaphase lag (difference in time of movement of sister chromatids to opposite polls), non-disjunction of sister chromatids (the failure of separation of sister chromatids), endoreplication (duplication of the chromosome is not followed by division of parental cell) lead to the development of cells with either higher number of chromosomes or a low number of chromosomes. This ultimately leads to diseases like Turner syndrome and Down syndrome. Faulty mitotic divisions due to mutational changes lead to the development of cells to form tumors and result in cancer.
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