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Expansion of a CAG repeat region by 1 repeat is an example of a frameshift mutation. Both DNA polymerase and RNA polymerase read their template strand in a 3'->5' direction. A silent mutation can create a RFLP.

Expansion of a CAG repeat region by 1 repeat is an example of a frameshift mutation. Both DNA polymerase and RNA polymerase read their template strand in a 3'->5' direction. A silent mutation can create a RFLP.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Expansion of a CAG repeat region by 1 repeat is an example of a frameshift mutation. Both DNA polymerase and RNA polymerase read their template strand in a 3'->5' direction. A silent mutation can create a RFLP. In an organism with genotype AbClaBc ; DE/DE, genes A and D are linked genes. In complementation tests, a dominant mutation will complement all other mutations. The closer two genes are on a chromosome, the more accurate their m.u. distance is. Sanger sequencing relies on using dideoxynucleotides to terminate extension of DNA from a primer. A linked RFLP (like the C RFLP banding pattern in the Venezuelan Huntington's Disease family)
Transcribed Image Text:Expansion of a CAG repeat region by 1 repeat is an example of a frameshift mutation. Both DNA polymerase and RNA polymerase read their template strand in a 3'->5' direction. A silent mutation can create a RFLP. In an organism with genotype AbClaBc ; DE/DE, genes A and D are linked genes. In complementation tests, a dominant mutation will complement all other mutations. The closer two genes are on a chromosome, the more accurate their m.u. distance is. Sanger sequencing relies on using dideoxynucleotides to terminate extension of DNA from a primer. A linked RFLP (like the C RFLP banding pattern in the Venezuelan Huntington's Disease family)
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