Enkephalins and endorphins are referred to as “nature’s opiates.” Explain this saying.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Enkephalins and endorphins are referred to as “nature’s opiates.” Explain this saying.

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Introduction

Opioids are a class of drugs that are addictive and function as pain relievers and as sedatives. Enkephalins are pentapeptide hormones that bind to the body's opioid receptors. Endorphins are natural opioids and neuropeptides that are released during the stress response. 

 

Explanation

The primary function of opioid drugs is pain relief and feeling of euphoria. The endorphins and enkephalins are called natural opiates because

  • the body releases them during stress response or fight-or-flight response.
  • These hormones' primary function is to reduce the perception of pain and reduce stress by triggering a positive feeling in the body.
  • These hormones also find in the body's opioid receptors.
  • Any opioid antagonists can lock the functions of these hormones.

 

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