Draw the structure of the EISTL peptide at physiological pH. b On your structure for part (a, CIRCLE the coplanar atoms in only one peptide bond. c. On your structure for part (a), BOX two hydrogen bond donors and STAR two hydrogen bond acceptors.

Biochemistry
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Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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One photo is the explanation and the other one is the question
Name
Shown to the right is a cartoon image of ETC Complex I
from Y. lipolytica. A group of authors studied this wild type
Complex I and also a version where the arginine at position
121 in the chain 3 subunit was mutated to a methionine
(R121M).
Transcribed Image Text:Name Shown to the right is a cartoon image of ETC Complex I from Y. lipolytica. A group of authors studied this wild type Complex I and also a version where the arginine at position 121 in the chain 3 subunit was mutated to a methionine (R121M).
Part of chain 3 subunit contains the peptide sequence EISTL.
Draw the structure of the EISTL peptide at physiological pH.
a.
b On your structure for part (a, CIRCLE the coplanar atoms in only one peptide bond.
On your structure for part (a), BOX two hydrogen bond donors and STAR two hydrogen bond
с.
acсeptors.
d. Calculate the pl for EISTL.
е.
Draw the titration curve for the EISTL peptide.
f. Mark all pKa's and the pl on
our curve.
For the EISTL peptide at physiological pH, explain what types of interactions you believe the
side chains are or are not able to participate in.
g.
Transcribed Image Text:Part of chain 3 subunit contains the peptide sequence EISTL. Draw the structure of the EISTL peptide at physiological pH. a. b On your structure for part (a, CIRCLE the coplanar atoms in only one peptide bond. On your structure for part (a), BOX two hydrogen bond donors and STAR two hydrogen bond с. acсeptors. d. Calculate the pl for EISTL. е. Draw the titration curve for the EISTL peptide. f. Mark all pKa's and the pl on our curve. For the EISTL peptide at physiological pH, explain what types of interactions you believe the side chains are or are not able to participate in. g.
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