Draw the structure of the EISTL peptide at physiological pH. b On your structure for part (a, CIRCLE the coplanar atoms in only one peptide bond. c. On your structure for part (a), BOX two hydrogen bond donors and STAR two hydrogen bond acceptors.
Draw the structure of the EISTL peptide at physiological pH. b On your structure for part (a, CIRCLE the coplanar atoms in only one peptide bond. c. On your structure for part (a), BOX two hydrogen bond donors and STAR two hydrogen bond acceptors.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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One photo is the explanation and the other one is the question

Transcribed Image Text:Name
Shown to the right is a cartoon image of ETC Complex I
from Y. lipolytica. A group of authors studied this wild type
Complex I and also a version where the arginine at position
121 in the chain 3 subunit was mutated to a methionine
(R121M).

Transcribed Image Text:Part of chain 3 subunit contains the peptide sequence EISTL.
Draw the structure of the EISTL peptide at physiological pH.
a.
b On your structure for part (a, CIRCLE the coplanar atoms in only one peptide bond.
On your structure for part (a), BOX two hydrogen bond donors and STAR two hydrogen bond
с.
acсeptors.
d. Calculate the pl for EISTL.
е.
Draw the titration curve for the EISTL peptide.
f. Mark all pKa's and the pl on
our curve.
For the EISTL peptide at physiological pH, explain what types of interactions you believe the
side chains are or are not able to participate in.
g.
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